牛俊奇 返回专家列表

       牛俊奇,男,1958年生,医学学士,传染病学硕士,免疫学博士学位,教授,一级主任医师,博士生导师。

       吉林省肝病研究所所长,吉林大学第一医院肝胆胰内科主任,吉林大学第一医院临床药理机构主任,《临床肝胆病杂志》主编,中国科学院上海巴斯德研究所和北华大学特聘教授,吉林省肝脏病学会委员会主任委员,吉林省传染病学会名誉主任委员,亚洲及太平洋地区肝病学会会员,欧洲肝病学会会员,美国肝病学会会员。

       第八版《传染病学》副主编,《中华传染病杂志》编委,《中华肝脏病杂志》编委,《中国免疫学杂志》编委,《中国实验诊断学》编委,《中国病毒病杂志》编委,《国际病毒学杂志》编委,《中华实验和临床感染病杂志》编委,《中国肝脏病杂志》(电子版)编委,《国际流行病传染病学杂志》编委,《Hepatobiliary & Pancreatic Diseases International》编委,

       国务院特殊津贴获得者,国家应急公共卫生事件专家吉林省专家组组长,

       吉林省暨长春市防控甲型H1N1流感专家组重症医疗救治组组长,

       吉林省暨长春市手足口病医疗救治工作专家组组长,

       2003年获得中共长春市委颁发的“抗非典优秀共产党员”称号,

       2003年获得吉林大学“抗非典优秀医务工作者”称号, 

       2003年获得“长春十大新闻人物”称号,2004被国家人事部,卫生部评为全国卫生系统先进工作者,

       2005年获得吉林省第八批有突出贡献的中青年专业技术人才,

       2005年获得吉林省第一批拔尖创新人才,

       2005年获得第一批“吉林省高级专家”称号,

       2006年被评为第二届吉林大学白求恩名医,

       2007年获得长春市卫生系统突发公共卫生事件应急处理先进个人称号,

       2008年度获得卫生部有突出贡献中青年专家称号,

       2008年获得第二批“吉林省高级专家”称号,

       2011年获得第三批“吉林省高级专家”称号,

       2013年获得吉林省科学技术一等奖,

       2014年获中华医学科技二等奖,

       1992年~1994年在英国伦敦大学博士后,

       1997年~1999年美国康奈狄克大学医学院高级访问学者。

       多年来一直从事传染病学的临床教学工作,同时积极开展病毒性丙型肝炎的实验和流行病学研究。在英国留学期间从事丙型肝炎病毒的细胞培养模型的建立,在美国留学期间进行丙型肝炎病毒的基因治疗研究。

       曾获得省部级科技进步二等奖两项,近年来在Hepatology,J Gastroenterol. Antiviral Res.  J Med Virol.等发表SCI检索的论文三十多篇。最高影响因子11.665

       专利:

       自动灌注式胆囊结石治疗仪,申请号:CN2012200690253  

       抗肝炎病毒的铌钨酸盐化合物,专利号:ZL201010192071.8

       无环核苷磷酸衍生物及其医药用途,申请号: 200710097600.4

       稀土杂多化合物抗病毒药物,专利号:ZL200610016659.1

       承担科研项目:

       “十二五”国家科技重大专项课题

       ( sponsored by National Science and Technology Major Project (2012ZX10002003) 

       (1)以清除HBVcccDNA为目标的“鸡尾酒”疗效研究,课题编号:2014ZX10002002,起止时间:2014-2016年,负责人:牛俊奇;经费:4275.41万元(其中任务一位1643.15万元)。

       (2)病毒性肝炎转归预警预测的研究,课题编号:2012ZX10002007-003,起止时间:2012-2015年,负责人:牛俊奇;经费:292.86万元。

       (3)慢性乙型肝炎临床治疗新方案研究,课题编号:2012ZX10002003-001,起止时间:2012-2015年,负责人:牛俊奇;经费:103.96万元。

       (4)慢性乙型肝炎临床治疗新方案研究,课题编号:2012ZX10002003-002,起止时间:2012-2015年,负责人:牛俊奇,金清龙;经费:66.22万元。

       (5)慢性乙型肝炎临床治疗新方案研究,课题编号:2012ZX10002003-005,起止时间:2012-2015年,负责人:牛俊奇,潘煜;经费:62.70万元。

       (6)慢性乙型肝炎临床治疗新方案研究,课题编号:2012ZX10002003-005,起止时间:2012-2015年,负责人:牛俊奇,姜晶;经费:29.20万元。

       (7)经乙型肝炎进展为肝癌的人源化小鼠和细胞模型的建立及个体化治疗,课题编号:2013ZX10002008-001-003,起止时间:2013-2015年,负责人:牛俊奇,金清龙;经费:220.68万元。

       (8)经乙型肝炎进展为肝癌的人源化小鼠和细胞模型的建立及个体化治疗,课题编号:2013ZX10002008-001-005,起止时间:2013-2015年,负责人:牛俊奇,迟秀梅;经费:51.92万元。      

       2."乙型病毒性肝炎临床治疗方案的研究及其优化”, 国家“十一五”科技国家重大专项课题,2008ZX10002-004,2008年,700万。

       3."稀土杂多化合物抗乙肝病毒药物研究.” 国家“十一五”科技支撑计划重点项目,2009年-2010年,负责人  250万。

       4.宿主遗传因素对抗乙型肝炎病毒治疗的影响,卫生部部属医院临床学科重点项目,200万,20073531。

       5.重大疾病的肝靶向治疗研究,863计划,200612-200812,290万,2006AA02Z4C6。

       6.国家自然科学基金课题/ U1SnRNA和核酶复合体靶向抑制HCV复制的研究/项目批准号/申请代码30070692/H1904/批准金额16万/项目起止年月2001-01至2003-12。

       7.国家自然科学基金课题/ RNA干涉用于抗HCV感染基因治疗的研究/项目批准号/申请代码30371271/H1904批准金额7万/项目起止年月2004-01至2004-12。

       8.国家自然科学基金课题/ RNA干涉抑制丙型肝炎病毒复制和表达/项目批准号/申请代码30410403287/H1904批准金额8万/项目起止年月2005-03至2005-03。

       9.国家自然科学基金课题/新型载体用于HBV基因治疗的实验研究/项目批准号/申请代码30571642/H1904批准金额20万/项目起止年月2006-01至2008-12。

       10.国家自然科学基金课题/核苷(酸)类似物治疗对慢乙肝患者免疫功能重建的作用及其机制/项目批准号/申请代码30771912/H1904/批准金额29万/项目起止年月2008-01至2010-12。

       11.国家自然科学基金课题/影响干扰素抗乙肝病毒疗效的功能基因组学和细胞免疫学的研究/项目批准号/申请代码30972611/H1904/批准金额35万/项目起止年月2010-01至2012-12。

       12.影响干扰素抗乙肝病毒疗效的功能基因组学和细胞免疫学的研究, 国家自然科学基金课题。35万,第一名。30972611,2010年-2012年。

       13.核苷(酸)类似物治疗对慢乙肝患者免疫功能重建的作用及其机制,国家自然科学基金课题。29万,第一名。30771912,2008年-2010年。

       14.新型载体用于HBV,HCV基因治疗的实验研究,国家自然科学基金课题。20万,第一名。30571642,2006年-2008年。

       15.HCV感染后病毒和宿主因素致肝硬化及肝癌前瞻性队列研究,项目编号81373057,2014-2017年,负责人:牛俊奇;经费:90万。

       16.慢性乙型肝炎免疫耐受和免疫清除机制的代谢组学研究。项目编号81172727, 2012-2015年,负责人:牛俊奇;经费:70万。

        科研成果:

       1.核苷(酸)类似物治疗对慢乙肝患者免疫功能重建的作用及其机制,吉林省科学技术一等奖,2013年

       2.多学科实施PBL教学模式,全面提升临床医学教育质量,吉林大学教学成果一等奖,2013年

       3.IL28B基因多态性极其高表达在HCV、HBV感染转归的临床作用,吉林大学医疗成果三等奖,2012年

       4.免疫学因素在慢性肝炎患者的作用研究,吉林省自然科学学术成果一等奖,2011年

       5.Fibroscan检测肝脏纤维化,吉林大学医疗成果三等奖, 2010年

       6.重视精品课程建设,保证临床医学教学质量(论文类),吉林省教育厅教学成果一等奖,2010年

       7.重视精品课程建设保证临床医学教学质量,吉林大学教学成果二等奖,2010年

       8.乙型病毒肝炎基因治疗的研究,吉林省科学技术进步二等奖,2007年

       9.Gc球蛋白检测对重症肝炎的诊断意义,吉林大学医疗成果二等奖,2007年

       10. 药物临床试验伦理委员会工作经验, 吉林大学医疗成果二等奖,2007年

       11. 研究耐甲氧西林金黄色葡萄球菌耐药性及分型的检测方法, 吉林大学医疗成果三等奖,2007年

       12.拉米夫定诱导YMDD变异监测及相关临床耐药的抢救治疗,吉林大学医疗成果三等奖,2007年

       13.护理干预提高慢性丙型肝炎诱发糖尿病患者生命质量的研究,吉林大学医疗成果三等奖,2007年

       14.丙型病毒性肝炎基因治疗的研究,吉林省科学进步二等奖,2004年

       15.甲型肝炎的特异性预防研究,吉林省科学进步三等奖,2002年

       16.《M2抗体,肝活检对原发胆汁淤积性肝硬化临床意义》,吉林大学医疗成果三等奖,2001年

       17.前列腺E治疗重症肝炎,获白求恩医科大学四等奖,1990年

       18. Hepatitis C Virus Type I(1a)in Northern China,被评为1994-1995年度一级优秀论著,白求恩医科大学科学技术学会,1995年。

       19. 吉林省不同人群丙型肝炎病毒感染状况调查研究,吉林省科委,1996年。

       20.特异性核酶,脱氧核用于HBV,HVC感染基因治疗现状,中国科协,一等, 2002年。

       21.基因工程口服甲肝疫苗的研制,中华人民共和国教育部鉴定。骨干,第一名,2001年。

       22. 特异性核酶,脱氧核抗HBV,HVC复制体外研究,中国药学会,优秀,2003年。

       23.胆石溶解仪研发项目结题鉴定,第二负责人,2004年。

       24.以病原生物学为载体的基础医学综合改革研究与实践。2005年吉林大学教学成果奖获奖项目,一等奖。

       25.以病原生物学为载体的基础医学综合改革研究与实践,三等奖,吉林省人民政府,2001—2004年吉林省高等教育省级教学成果奖,2005年

       教学:已培养博士及硕士研究生100余名。

发表论著:

  1. IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection

 Infect Genet Evol. 2016.  April 2016, Pages 132–140

  2. ssDNA Aptamer Specifically Targets and Selectively Delivers Cytotoxic Drug Doxorubicin to HepG2 Cells.

PLoS One. 2016

  3. Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients.

Gastroenterol Hepatol. 2016 Jan 9. doi: 10.1111/jgh.13290

  4. Characteristics of CD4(+)CD25(+)Foxp3(+) regulatory T cells in patients with multiple organ dysfunction syndrome. Exp Ther Med. 2016.

  5. Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients.

 Eur J Gastroenterol Hepatol. 2016.

  6.Red Blood Cell Distribution Width to Platelet Ratio is Related to Histologic Severity of Primary Biliary Cirrhosis.

Wang H, et al. Medicine (Baltimore). 2016.

  7. Characteristics of PCR-SSCP and RAPD-HPCE methods for identifying authentication of Penis et testis cervi in Traditional Chinese Medicine based on cytochrome b gene.

Mitochondrial DNA A DNA MappSeq Anal. 2016.

  8. Development of multiplex PCR assay for authentication of Cornu Cervi Pantotrichum in traditional Chinese medicine based on cytochrome b and C oxidase subunit 1 genes.

Mitochondrial DNA A DNA MappSeq Anal. 2016.

  9.Interferon alpha (IFN伪)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A.

  Cell Mol Immunol. 2016.

  10.Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.

Randomized controlled trial

Gut. 2016.

  11.Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells.

 Int J Mol Sci. 2016.

  12.A nationwide survey of specialist knowledge on current standard of care (Peg-IFN/RBV) and barriers of care in chronic hepatitis C patients in China.

 J Gastroenterol Hepatol. 2016.

  13.Working together to promote the development of hepatology in China.

 Zhonghua Gan Zang Bing Za Zhi. 2016.

  14.Mutation of Glycosylation Sites in BST-2 Leads to Its Accumulation at Intracellular CD63-Positive Vesicles without Affecting Its Antiviral Activity against Multivesicular Body-Targeted HIV-1 and Hepatitis B Virus. Viruses. 2016.

  15.Hepatitis C virus regulates the production of monocytic myeloid-derived suppressor cells from peripheral blood mononuclear cells through PI3K pathway and autocrine signaling.

 Clin Immunol. 2016.

  16.IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection.

Infect Genet Evol. 2016

  17.A comparison of the prevalence and clustering of major cardiovascular risk factors in the Netherlands and China.

Review article.Eur J Prev Cardiol. 2016.

  18. Sui M, Wu R, Hu X, Zhang H, Jiang J, Yang Y, Niu J. Low prevalence of hepatitis B virus infection in patients with autoimmune diseases in a Chinese patient population. J Viral Hepat. 2014 Aug 20. doi: 10.1111/jvh.12302. [Epub ahead of print]

  19.Kong F, Pan Y, Chi X, Wang X, Chen L, Lv J, Sun H, Wu R, Jin J, Yu G, Ma Z, Wang Y, Huang X, Li H, Bai Y, Jia J, Minuk GY, Zhong J, Sun B, Jiang J, Niu J. Factors associated with spontaneous clearance of hepatitis C virus in chinese population. Biomed Res Int. 2014;2014:527030. doi: 10.1155/2014/527030. Epub 2014 Jul 16.

  20.Wei Q, Sun J, Huang J, Zhou HY, Ding YM, Tao YC, He SM, Liu YL, Niu JQ. Prevalence of hypertension and associated risk factors in Dehui City of Jilin Province in China. J Hum Hypertens. 2014 Jul 3. doi: 10.1038/jhh.2014.32. [Epub ahead of print]

  21.Tian S, Chang HH, Wang C, Jiang J, Wang X, Niu J. Multi-TGDR, a multi-class regularization method, identifies the metabolic profiles of hepatocellular carcinoma and cirrhosis infected with hepatitis B or hepatitis C virus. BMC Bioinformatics. 2014 Apr 4;15:97. doi: 10.1186/1471-2105-15-97.

  22.Bility MT, Cheng L, Zhang Z, Luan Y, Li F, Chi L, Zhang L, Tu Z, Gao Y, Fu Y, Niu J, Wang F, Su L. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages.  PLoS Pathog. 2014 Mar 20;10(3):e1004032. doi: 10.1371/journal.ppat.1004032. eCollection 2014 Mar.

  23. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Liu F, You X, Chi X, Wang T, Ye L, Niu J, Zhang X. Biochem Biophys Res Commun. 2014 Feb 7;444(2):128-34. doi: 10.1016/j.bbrc.2014.01.004. Epub 2014 Jan 14.

  24. Chen W, Xu Y, Li H, Tao W, Xiang Y, Huang B, Niu J, Zhong J, Meng G. HCV genomic RNA activates the NLRP3 inflammasome in human myeloid cells. PLoS One. 2014 Jan 6;9(1):e84953.

  25. Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J. Long-term effect on natural killer cells by interferon-a therapy on the outcomes of HCV infection. J Interferon Cytokine Res. 2014 May;34(5):366-75. doi: 10.1089/jir.2013.0049. Epub 2013 Dec 24.

  26. Sun H, Lv J, Tu Z, Hu X, Yan H, Pan Y, Xu D, Lian Z, Chi X, Niu J. Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients. Exp Biol Med (Maywood). 2013 Nov 1;238(11):1275-83. doi: 10.1177/1535370213502626. Epub 2013 Oct 1.

  27. Zhang M, Wu R, Jiang J, Minuk GY, Niu J. The presence of hepatitis B core antibody is associated with more advanced liver disease in alcoholic patients with cirrhosis. Alcohol. 2013 Nov;47(7):553-8. doi: 10.1016/j.alcohol.2013.07.003. Epub 2013 Sep 13.

  28. Qi Y, Xiang Y, Wang J, Qi Y, Li J, Niu J, Zhong J. Inhibition of hepatitis C virus infection by polyoxometalates. Antiviral Res. 2013 Nov;100(2):392-8. doi: 29. 1016/j.antiviral.2013.08.025. Epub 2013 Sep 8.

  30. Tu Z, Zhang P, Li H, Niu J, Jin X, Su L. Cross-linking of CD81 by HCV-E2 protein inhibits human intrahepatic plasmacytoid dendritic cells response to CpG-ODN. Cell Immunol. 2013 Jul-Aug;284(1-2):98-103. doi: 10.1016/j.cellimm.2013.07.012. Epub 2013 Aug 2.

  31. Ji HF, Wang J, Yu L, Niu JQ, Ayana DA, Jiang YF. High frequencies of CD158b+ NK cells are associated with persistent hepatitis C virus infections. Ann Hepatol. 2013 Jul-Aug; 12(4):539-47

  32. Ding Y, Zhang H, Li Y, Wu D, He S, Wang Y, Li Y, Wang F, Niu J. Inhibition of HCV 5'-NTR and core expression by a small hairpin RNA delivered by a histone gene carrier, HPhA. Int J Med Sci. 2013 Jun 9;10(8):957-64. doi: 10.7150/ijms.5632. Print 2013.

  33. Lv J, Jin Q, Sun H, Chi X, Hu X, Yan H, Pan Y, Xiao W, Tian Z, Hou J, Xu D, Tu Z, Niu J. Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic hepatitis B virus infected patients. Mediators Inflamm. 2012;2012:804043. doi: 10.1155/2012/804043. Epub 2012 Dec 10.

  34. Zhao PW, Jia FY, Shan YX, Ji HF, Feng JY, Niu JQ, Ayana DA, Jiang YF. Downregulation and altered function of natural killer cells in hepatitis B virus patients treated with entecavir.  Clin Exp Pharmacol Physiol. 2013 Mar;40(3):190-6. doi: 10.1111/1440-1681.12048.

  35. Ma L, Cai YJ, Yu L, Feng JY, Wang J, Li C, Niu JQ, Jiang YF. Treatment with telbivudine positively regulates antiviral immune profiles in Chinese patients with chronic hepatitis B. Antimicrob Agents Chemother. 2013 Mar;57(3):1304-11. doi: 10.1128/AAC.02181-12. Epub 2012 Dec 28.

  36. Zhang H, Ding Y, Li Q, Sun J, He S, Feng X, Zhao Y, Zhou X, Cai Y, Wang C, Shi X, Wang Z, Zhou Q, Niu J. Relationship between Serum Aminotransferase Levels and Metabolic Disorders in Northern China. Iran J Public Health. 2012;41(2):15-26. Epub 2012 Feb 29.

  37. Jia Z, Ding Y, Tian S, Niu J, Jiang J. Test of IL28B polymorphisms in chronic hepatitis C patients treated with PegIFN and ribavirin depends on HCV genotypes: results from a meta-analysis. PLoS One. 2012;7(9):e45698. doi: 10.1371/journal.pone.0045698. Epub 2012 Sep 21.

  38. Shi X, Pan Y, Wang M, Wang D, Li W, Jiang T, Zhang P, Chi X, Jiang Y, Gao Y, Zhong J, Sun B, Xu D, Jiang J, Niu J. IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population. PLoS One. 2012;7(5):e37054. doi: 10.1371/journal.pone.0037054. Epub 2012 May 23.

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  40. Wang X, Zhu C, Bao W, Zhao K, Niu J, Yu XF, Zhang W. Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China. PLoS One. 2012;7(3):e32405. doi: 10.1371/journal.pone.0032405. Epub 2012 Mar 29.

  41. Feng J, Hu X, Guo H, Sun X, Wang J, Xu L, Jiang Z, Xu B, Niu J, Jiang Y. Patients with chronic hepatitis C express a high percentage of CD4(+)CXCR5(+) T follicular helper cells. J Gastroenterol. 2012 Sep;47(9):1048-56. doi: 10.1007/s00535-012-0568-1. Epub 2012 Mar 17.

  42. He S, Bao W, Shao M, Wang W, Wang C, Sun J, Jiang Y, Feng X, Niu J. Risk factors for non-alcoholic fatty liver disease in a Chinese population. Acta Gastroenterol Belg. 2011 Dec;74(4):503-8.

  43. Wang J, Zhao P, Guo H, Sun X, Jiang Z, Xu L, Feng J, Niu J, Jiang Y. Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis C. Mediators Inflamm. 2012;2012:819636. doi: 10.1155/2012/819636. Epub 2012 Jan 24.

  44. Wang J, Cai Y, Ji H, Feng J, Ayana DA, Niu J, Jiang Y. Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B. J Interferon Cytokine Res. 2012 Jun;32(6):248-53. doi: 10.1089/jir.2011.0109. Epub 2012 Feb 3.

  45. Zhang H, Qi Y, Ding Y, Wang J, Li Q, Zhang J, Jiang Y, Chi X, Li J, Niu J. Synthesis, characterization and biological activity of a niobium-substituted-heteropolytungstate on hepatitis B virus. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1664-9. doi: 10.1016/j.bmcl.2011.12.115. Epub 2012 Jan 2.

  46. Jin J, Niu J, Kim YM, Wang X, Parham D, Letton R, Li S, Lee JY. A novel t(8;13)(q21;q22) translocation in a pediatric lipoma. Cancer Genet. 2011 Nov;204(11):629-33. doi: 10.1016/j.cancergen.2011.10.010. Review.

  47. Jin Q, Moritoki Y, Lleo A, Tsuneyama K, Invernizzi P, Moritoki H, Kikuchi K, Lian ZX, Hirschfield GM, Ansari AA, Coppel RL, Gershwin ME, Niu J. Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis. Hepatology. 2012 May;55(5):1495-506. doi: 10.1002/hep.25511. Epub 2012 Apr 4.

  48. Qi YF, Zhang H, Wang J, Jiang Y, Li J, Yuan Y, Zhang S, Xu K, Li Y, Li J, Niu J, Wang E. In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate. Antiviral Res. 2012 Jan;93(1):118-25. doi: 10.1016/j.antiviral.2011.11.003. Epub 2011 Nov 23.

  49. Etiology and prevalence of abnormal serum alanine aminotransferase levels in a general population in Northeast China.  Zhang H, Jiang YF, He SM, Sun J, Gu Q, Feng XW, DU B, Wang W, Shi XD, Wang CY, Zhang SQ, Li WY, Niu JQ.  Chin Med J (Engl). 2011 Sep;124(17):2661-8.

  50. Piao RL, Liu YY, Tian D, Ma ZH, Zhang M, Zhao C, Niu JQ. Adefovir dipivoxil modulates cytokine expression in Th1/Th2 cells in patients with chronic hepatitis B. Mol Med Rep. 2012 Jan;5(1):184-9. doi: 10.3892/mmr.2011.627. Epub 2011 Oct 11.

  51. Li W, Jiang Y, Jin Q, Shi X, Jin J, Gao Y, Pan Y, Zhang H, Jiang J, Niu J. Expression and gene polymorphisms of interleukin 28B and hepatitis B virus infection in a Chinese Han population. Liver Int. 2011 Sep;31(8):1118-26. doi: 10.1111/j.1478-3231.2011.02507.x. Epub 2011 Mar 30.

  52. Zhang H, Li Q, Sun J, Wang C, Gu Q, Feng X, Du B, Wang W, Shi X, Zhang S, Li W, Jiang Y, Feng J, He S, Niu J. Seroprevalence and risk factors for hepatitis B infection in an adult population in Northeast China. Int J Med Sci. 2011;8(4):321-31. Epub 2011 May 20.

  53. Zhang H, He SM, Sun J, Wang C, Jiang YF, Gu Q, Feng XW, Du B, Wang W, Shi XD, Zhang SQ, Li WY, Niu JQ. Prevalence and etiology of abnormal liver tests in an adult population in Jilin, China. Int J Med Sci. 2011 Mar 25;8(3):254-62.

  54. Jiang YF, Ma ZH, Zhao PW, Pan Y, Liu YY, Feng JY, Niu JQ. Effect of thymosin-a (1) on T-helper 1 cell and T-helper 2 cell cytokine synthesis in patients with hepatitis B virus e antigen-positive chronic hepatitis B. J Int Med Res. 2010;38(6):2053-62.

  55. Shi XD, He SM, Tao YC, Wang CY, Jiang YF, Feng XW, Sun J, Niu JQ. Prevalence of obesity and associated risk factors in Northeastern China. Diabetes Res Clin Pract. 2011 Mar;91(3):389-94. doi: 10.1016/j.diabres.2010.11.002. Epub 2010 Dec 4.

  56. Jiang Y, Ma Z, Xin G, Yan H, Li W, Xu H, Hao C, Niu J, Zhao P. Th1 and Th2 immune response in chronic hepatitis B patients during a long-term treatment with adefovir dipivoxil. Mediators Inflamm. 2010;2010:143026. doi: 10.1155/2010/143026. Epub 2010 Nov 29.

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  58. Li WY, Jiang YF, Jin QL, Zhang H, Feng XW, Niu JQ. Immunologic characterization of posthepatitis cirrhosis caused by HBV and HCV infection. J Biomed Biotechnol. 2010;2010:138237. doi: 10.1155/2010/138237. Epub 2010 Jun 15.

  59. Wang W, Kong J, Sun J, Wang CY, Chen HY, Jiang YF, Feng XW, He SM, Niu JQ. Epidemiological investigation of metabolic syndrome and analysis of relevant factors in north-eastern China. J Int Med Res. 2010 Jan-Feb;38(1):150-9.

  60. Piao YF, Tang TY, Niu JQ, Wang F. Construction of eukaryotic expression plasmids of hepatitis B surface antigen and helper T lymphocyte epitope. Hepatobiliary Pancreat Dis Int. 2004 May;3(2):219-22.

  61. Sun J, Xie Q, Tan D, Ning Q, Niu J, Bai X, Fan R, Chen S, Cheng J, Yu Y, Wang H, Xu M, Shi G, Wan M, Chen X, Tang H, Sheng J, Dou X, Shi J, Ren H, Wang M, Zhang H, Gao Z, Chen C, Ma H, Jia J, Hou J. The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study. Hepatology. 2014 Apr;59(4):1283-92. doi: 10.1002/hep.26885. Epub 2014 Feb 28.

  62. Deng YR, Yoshida K, Jin QL, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu JQ, Matsuzaki K, Lian ZX.Reversible phospho-Smad3 signalling between tumour suppression and fibrocarcinogenesis in chronic hepatitis B infection. Clin Exp Immunol. 2014 Apr;176(1):102-11. doi: 10.1111/cei.12259.

  63. Rao H, Wei L, Lopez-Talavera JC, Shang J, Chen H, Li J, Xie Q, Gao Z, Wang L, Wei J, Jiang J, Sun Y, Yang R, Li H, Zhang H, Gong Z, Zhang L, Zhao L, Dou X, Niu J, You H, Chen Z, Ning Q, Gong G, Wu S, Ji W, Mao Q, Tang H, Li S, Wei S, Sun J, Jiang J, Lu L, Jia J, Zhuang H. Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2014 Mar;29(3):545-53. doi: 10.1111/jgh.12398.

  64. Wang Y, Thongsawat S, Gane EJ, Liaw YF, Jia J, Hou J, Chan HL, Papatheodoridis G, Wan M, Niu J, Bao W, Trylesinski A, Naoumov NV. Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B. J Viral Hepat. 2013 Apr;20(4):e37-46. doi: 10.1111/jvh.12025. Epub 2012 Dec 27.

  65. Zhou L1, Ding L, Yin P, Lu X, Wang X, Niu J, Gao P, Xu G. Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry. J Proteome Res. 2012 Nov 2;11(11):5433-42. doi: 10.1021/pr300683a. Epub 2012 Sep 28.

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  68. Xu DZ1, Zhao K, Guo LM, Li LJ, Xie Q, Ren H, Zhang JM, Xu M, Wang HF, Huang WX, Bai XF, Niu JQ, Liu P, Chen XY, Shen XL, Yuan ZH, Wang XY, Wen YM.A randomized controlled phase IIb trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients. PLoS One. 2008 Jul 2;3(7):e2565. doi: 10.1371/journal.pone.0002565.

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  77. Jiang YF, Zhao PW, Qin JJ, Li MH, Yasushi M, Niu JQ. [The effect of DHEA on AKT signal pathway on transplanted Morris hepatomas in rats]. Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):679-82. Chinese.

  78. Zhang KY, Niu JQ. [Hepatorenal syndrome: current diagnostic and therapeutic concepts]. Zhonghua Gan Zang Bing Za Zhi. 2008 Jun;16(6):410-1. Chinese. No abstract available.

  79. Jiang YF, Zhao PW, Tan Y, Liu LH, Li MH, Matsuzaki Y, Niu JQ. [Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]. Zhonghua Gan Zang Bing Za Zhi. 2007 Jun;15(6):441-4. Chinese.

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  81. Wang MX, Jin QL, Pan Y, Wang F, Niu JQ. [Inhibition of HCV replication by HCV specific U1 small nuclear RNA chimeric ribozyme in vivo]. Zhonghua Gan Zang Bing Za Zhi. 2006 Jan;14(1):11-4. Chinese.

  82. Wen XY, Bao WG, Yang XY, Tian MM, Wang F, Niu JQ. [Cleavage of HCV by HCV specific deoxyribozyme in vitro]. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):900-2. Chinese.

  83. Ren N, Wang F, Niu JQ. [A study of 10-23 DNAzyme inhibiting the expression of hepatitis B virus genes]. Zhonghua Gan Zang Bing Za Zhi. 2005 Oct;13(10):745-8. Chinese.

  84. Gao SQ, Niu JQ, Wang F, Liu XD, Jin ZX, Wang YL. [Comparative studies on the resistance of hepatitis B by Syringa extract, IFN and ganyanling in HepG2.2.15 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Jul;19(4):385-6. Chinese.

  85. Chen X, Niu J, Wang F, Liu W. [Measurement of anti-acetaldehyde protein adduct IgA, IgG, IgM antibody titers in the sera of human alcoholics]. Zhonghua Gan Zang Bing Za Zhi. 2002 Oct;10(5):350, 353. Chinese. No abstract available.

  86. Wang M, Wang F, Niu J. [The construction of HCV specific U1 small nuclear RNA chimeric ribozyme]. Zhonghua Gan Zang Bing Za Zhi. 2002 Oct;10(5):346. Chinese. No abstract available.

  87. Zhao H, Si CW, Wei L, Wan MB, Ying YK, Hou JL, Niu JQ. [A multicenter, randomized, open-label study of the safety and effectiveness of pegylated interferon alpha 2b and interferon alpha 2b in treating HBeAg positive chronic hepatitis B patients]. Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):323-6. Chinese.

  88. Li YJ, Zhuang H, Li J, Dong QM, Chen YJ, Niu JQ, Ma WM, Zhao W, Zhao BA, Zhong JQ. [Distribution and clinical significance of hepatitis B virus (HBV) genotypes and subtypes in HBV-infected patients]. Zhonghua Gan Zang Bing Za Zhi. 2005 Oct;13(10):724-9. Chinese.

  89. Tian MM, Wang F, Niu JQ, Wang MX. [Study on the cleavage activity of U1 small nuclear RNA chimeric ribozyme against HCV RNA in vitro]. Zhonghua Gan Zang Bing Za Zhi. 2004 Dec;12(12):749-51. Chinese.

  90. Gao SQ, Niu JQ, Wang F, Liu XD, Jin ZX, Wang YL.  [Comparative studies on the resistance of hepatitis B by Syringa extract, IFN and ganyanling in HepG2.2.15 cells].  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Jul;19(4):385-6. Chinese.

  主译著作

  牛俊奇,张清泉,丁艳华主译,肝病手册,2006年9月出版,天津科技翻译出版公司。

  牛俊奇,肝炎和其他肝病 2008 年7月,吉林人民出版社

  牛俊奇主译 肝胆系统疾病 ( Diseases of the Liver & Biliary System by Shiela Sherlock and James Doole)天津科技翻译出版公司

  牛俊奇主译 病毒性肝炎( Viral Hepatitis  作者 HYPERLINK"http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&sort=relevancerank&search-alias=books&field-author=Howard%20C.%20Thomas" Howard C. Thomas)天津科技翻译出版公司