胡锦辉，复旦大学医学博士, 美国NIH博士后，副主任技师，美国免疫学家学会、上海市欧美同学会等学会成员，International Immunopharmacology, Scientific Reports, Journal of Cellular Biochemistry, Stem Cells, Cell Transplatation等杂志审稿人。发表包括 Nature Immunology、Blood、PNAS等杂志文章30篇，其中第一作者及通讯作者10篇，单篇最高IF＞17。有15年医院检验科一线工作经历，有12年医学免疫学研究经历，目前从事新型抗瘤细胞研究。共参与美国国立卫生研究院课题5项，中国国家自然科学基金5项，承担并完成上海市浦东新区科委及上海市女性生殖内分泌重点实验室开放课题各1项，一项主要完成人的工作获得FDA批准进入临床Ⅰ期试验。获得中国教育部第十届“春晖杯”留学人员创新创业大赛优胜奖，International Immunopharmacology优秀审稿人等荣誉。
【主要文章】
Sirt1 is critical for CD8+ T cells persistence and anti-tumor ability through stablizing TAG metabolism. Manuscript is being prepared.
Sabatino, M., Hu, J.#(胡锦辉，共同第一作者), Sommariva, M., Gautam, S., Fellowes, V., Hocker, J. D., Dougherty, S., Qin, H., Klebanoff, C. A., Fry, T. J., Gress, R. E., Kochenderfer, J. N., Stroncek, D. F., Ji, Y. & Gattinoni, L. Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies. Blood 128, 519-528, doi:10.1182/blood-2015-11-683847 (2016).
Hu, J.(胡锦辉), Meng, W., Zhang, D., Qiu, C., Hua, L., Xie, Q., He, X. & Ye, H. Th17-relevant cytokines vary with sera of different ANA staining patterns. International immunopharmacology 15, 679-684, doi:10.1016/j.intimp.2013.03.001 (2013).
Hu, J.(胡锦辉), Ye, H., Zhang, D., Liu, W., Li, M., Mao, Y. & Lu, Y. U87MG glioma cells overexpressing IL-17 acclerate early-stage growth and cause a higher level of CD31 mRNA expression in tumor tissues. Oncology letters 6, 993-999, doi:10.3892/ol.2013.1518 (2013).
Hu, J.(胡锦辉), Zhang, Y., Liu, X., Wei, L. & Zhang, D. Relationship between certain T helper cytokines and ANA staining: Who is the helper? International immunopharmacology 24, 208-210, doi:10.1016/j.intimp.2014.12.017 (2015).
Hu, J.(胡锦辉), Mao, Y., Li, M. & Lu, Y. The profile of Th17 subset in glioma. International immunopharmacology 11, 1173-1179, doi:10.1016/j.intimp.2011.03.015 (2011).
Qiu, C., Xie, Q., Zhang, D., Chen, Q., Hu, J.*(胡锦辉，共同通讯作者) & Xu, L. GM-CSF induces cyclin D1 expression and proliferation of endothelial progenitor cells via PI3K and MAPK signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 33, 784-795, doi:10.1159/000358652 (2014).
胡锦辉，CircRNA在自身免疫疾病中的研究进展。免疫学杂志，2021，37(07)：639-644
胡锦辉，邱潮林，华玲，谢秋华，何小雪，沈振华，胡珺。IL-17真核表达载体构建及其在胶质瘤细胞株U87MG中的表达与筛选。现代免疫学，2013.33(2): 107-112
胡锦辉，毕胜利，吕元。Th17——正逐步获得深入研究。中国免疫学杂志2012.Apr;28(4)372-378
胡锦辉，毕胜利，沈振华，李敏，宋燕，杜昕，关明，吕元。U87MG培养上清致Naïve CD4+ T细胞分化为Th2降低。免疫学杂志 2012.Apr;28(4)300-304
Ji, Y., Fioravanti, J., Zhu, W., Wang, H., Wu, T., Hu, J.(胡锦辉), Lacey, N. E., Gautam, S., Le Gall, J. B., Yang, X., Hocker, J. D., Escobar, T. M., He, S., Dell'Orso, S., Hawk, N. V., Kapoor, V., Telford, W. G., Di Croce, L., Muljo, S. A., Zhang, Y., Sartorelli, V. & Gattinoni, L. miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate. Nat Commun 10, 2157, doi:10.1038/s41467-019-09882-8 (2019).
Yao, C., Sun, H. W., Lacey, N. E., Ji, Y., Moseman, E. A., Shih, H. Y., Heuston, E. F., Kirby, M., Anderson, S., Cheng, J., Khan, O., Handon, R., Reilley, J., Fioravanti, J., Hu, J.(胡锦辉), Gossa, S., Wherry, E. J., Gattinoni, L., McGavern, D. B., O'Shea, J. J., Schwartzberg, P. L. & Wu, T. Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection. Nat Immunol 20, 890-901, doi:10.1038/s41590-019-0403-4 (2019).
Gautam, S., Fioravanti, J., Zhu, W., Le Gall, J. B., Brohawn, P., Lacey, N. E., Hu, J.(胡锦辉), Hocker, J. D., Hawk, N. V., Kapoor, V., Telford, W. G., Gurusamy, D., Yu, Z., Bhandoola, A., Xue, H. H., Roychoudhuri, R., Higgs, B. W., Restifo, N. P., Bender, T. P., Ji, Y. & Gattinoni, L. The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity. Nat Immunol 20, 337-349, doi:10.1038/s41590-018-0311-z (2019).
Ji, Y., Wrzesinski, C., Yu, Z., Hu, J.(胡锦辉), Gautam, S., Hawk, N. V., Telford, W. G., Palmer, D. C., Franco, Z., Sukumar, M., Roychoudhuri, R., Clever, D., Klebanoff, C. A., Surh, C. D., Waldmann, T. A., Restifo, N. P. & Gattinoni, L. miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic gammac cytokines. Proceedings of the National Academy of Sciences of the United States of America 112, 476-481, doi:10.1073/pnas.1422916112 (2015).
Klebanoff, C. A., Crompton, J. G., Leonardi, A. J., Yamamoto, T. N., Chandran, S. S., Eil, R. L., Sukumar, M., Vodnala, S. K., Hu, J.(胡锦辉), Ji, Y., Clever, D., Black, M. A., Gurusamy, D., Kruhlak, M. J., Jin, P., Stroncek, D. F., Gattinoni, L., Feldman, S. A. & Restifo, N. P. Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. JCI Insight 2, doi:10.1172/jci.insight.95103 (2017).
Li, M., Cheung, G. Y., Hu, J.(胡锦辉), Wang, D., Joo, H. S., Deleo, F. R. & Otto, M. Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. The Journal of infectious diseases 202, 1866-1876, doi:10.1086/657419 (2010).
Li, M., Du, X., Villaruz, A. E., Diep, B. A., Wang, D., Song, Y., Tian, Y., Hu, J.(胡锦辉), Yu, F., Lu, Y. & Otto, M. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nature medicine 18, 816-819, doi:10.1038/nm.2692 (2012).
* Co Corresponding author; # Co First author