傅德皓,上海交通大学骨科学教授、主任医师、博导,上海交通大学附属第一人民医院 创伤骨科主任。
主攻创伤骨科,擅长微创技术治疗脊柱、骨盆及四肢骨折;擅长显微外科技术(皮瓣移植术和骨移植术)治疗骨科疑难病症如骨髓炎、骨或软组织缺损、伤口或骨折不愈合以及关节僵硬、四肢畸形的修复重建。
社会任职:
国际肢体延长与重建学会(ILLRS)中国部委员
SICOT中国部创伤学会委员
中国骨科菁英会 (创伤)会员
中国医学救援协会创伤分会理事、秘书长
CAOS外固定与肢体重建学组、骨科康复学组委员
中国康复医学会修复重建外科继续教育工作委员会委员
中国老年学和老年医学学会骨质疏松分会基础医学专家委员会委员
中国研究型医院学会骨科创新与转化专业委员会骨与关节感染学组委员
CAOS青委会骨盆骨折学组委员
中国医药教育协会青年委员会委员
中华医学会创伤学分会青年委员会委员
《实用骨科杂志》《创伤外科杂志》编委
《中华实验外科杂志》《中国骨与关节杂志》通讯编委
研究方向:
主要从事骨质疏松症及骨松性骨折的基础与临床研究,致力于骨靶向药物的精准递送。先后主持国家自然科学基金青年及面上项目5项,以第一作者/通讯作者在Bioactive Materials、Pharmacology & Therapeutics、Redox Biology、Journal of Nanobiotechnology(JNB)、Journal of Bone and Joint Surgery-American Volume(JBJS)、Clinical Orthopaedics and Related Research(CORR)等期刊发表SCI论文近30篇,影响因子大于5的论文7篇,影响因子大于10的论文4篇,申请国家发明专利10余项,获批实用新型专利12项。
国家级课题(主持国自然5项,在研2项)
代表著作:
Yongzhi Cui#, Yuanyuan Guo#, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu*. A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis. Bioactive Materials. 2022 (10): 207-221.
DOI:10.1016/j.bioactmat.2021.09.015 2020IF= 14.593
Yu He#, Zhong-Hua Guo#, Yong-Guang Wu#, Rui Li, Xie Xie* and De-Hao Fu*. Customized treatment protocols for patients with closed fracture in hospitals at varying coronavirus disease 2019 (COVID19) risk. BMC Musculoskelet Disord. 2021 Aug 30;22(1):743. 2020IF= 2.362
Yuanyuan Guo#, Yongwei Liu#, Chen Shi#, Tingting Wu, Yongzhi Cui, Siyuan Wang, Ping Liu, Xiaobo Feng, Yu He, Dehao Fu*. Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats. J Nanobiotechnology. 2021 Aug 18;19(1):248. doi: 10.1186/s12951-021-00976-4. 2020IF= 10.435
Yuanyuan Guo#, Xiong Jia#, Yongzhi Cui, Yu Song, Siyuan Wang, Yongtao Geng, Rui Li, Weihang Gao, Dehao Fu*. Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis. Redox Biol. 2021 Feb 24;41:101915. doi: 10.1016/j.redox.2021.101915. Online ahead of print. 2020IF= 11.799
Songxiang Liu#, Baojun Xiao#, Ping Liu, Youxiu Wei, Yongwei Liu, Dehao Fu*. New Concealed-Incision Extrapelvic Approach for Pubic Symphysis Diastasis and Parasymphyseal Fractures: Preliminary Results. J Bone Joint Surg Am. 2020 Sep 2;102(17):1542-1550. (唯一通讯) doi: 10.2106/JBJS.19.01152. 2020IF=5.284
Jue-Ping Feng#*, Ru Zhu#, Fagang Jiang, Jie Xie, Chang Gao, Min Li, Honglin Jin, Dehao Fu*. Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides. Biomater Sci. 2020 Aug 11;8(16):4559-4569. doi: 10.1039/c9bm02080b. (共同通讯) 2020IF= 6.843 Biomaterials Science ISSN: 2047-4830 中科院2020版Q2
Yuan-yuan Guo, Lu Huang, Zhi-ping Zhang, De-hao Fu*. Strategies for Precise Engineering and Conjugation of Antibody Targeted-nanoparticles for Cancer Therapy. Current Medical Science (CURR MED SCI), 40(3), 463-473. (唯一通讯) DOI:10.1007/s11596-020-2200-6
Yuling Bao, Qian Hu, Xiuping Wang, Xiaobo Feng, Yu He, Yuanyuan Guo*, Dehao Fu*. Chemo-Immunotherapy with Doxorubicin Prodrug and Erythrocyte Membrane-Enveloped Polymer Nano-Vaccine Enhances Antitumor Activity. iomed Pharmacother. 2020 Sep;129:110377. doi: 10.1016/j.biopha.2020.110377. Epub 2020 Jun 15. (共同通讯) 2020IF= 6.529 Biomed Pharmacother 0753-3322 Biomedicine & Pharmacotherapy,中科院2020版Q2 0753-3322
Shi Chen, Wu Tingting, He Yu, Zhang Yu, Fu Dehao*. Recent advances in bone-targeted therapy. Pharmacol Ther. 2020 Mar;207:107473. doi: 10.1016/j.pharmthera.2020.107473. Epub 2020 Jan 8. PMID: 31926198. (唯一通讯) 2020IF=12.31
Feng X, Lin T, Liu X,Yang C, Yang S, Fu D. Long non-coding RNA BDNF-AS modulates osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Mol Cell Biochem. 2018 Aug;445(1-2):59-65. doi: 10.1007/s11010-017-3251-2. 2018 IF=2.884